Creatinine Clearance (Cockcroft-Gault) — Free Online Calculator
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Creatinine Clearance
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About This Calculator
Creatinine clearance (CrCl) estimates kidney function and is commonly used for drug dosing adjustments. The Cockcroft-Gault equation estimates CrCl from serum creatinine, age, weight, and sex. Unlike eGFR, this value is not normalized to body surface area, making it particularly useful for drug dosing in clinical practice.
Formula
Interpretation
| CrCl (mL/min) | Kidney Function |
|---|---|
| ≥ 90 | Normal |
| 60 – 89 | Mild decrease |
| 30 – 59 | Moderate decrease |
| 15 – 29 | Severe decrease |
| < 15 | Kidney failure |
Frequently Asked Questions
When should I use Cockcroft-Gault instead of CKD-EPI?
Cockcroft-Gault is commonly used for drug dosing adjustments because many drug studies used this equation to define renal impairment categories. CKD-EPI is preferred for CKD staging and general kidney function assessment.
Does Cockcroft-Gault use ideal or actual body weight?
The original formula uses actual body weight. However, in obese patients (>120% IBW), many clinicians use adjusted body weight to avoid overestimation. In underweight patients, actual body weight is typically used.
Why does creatinine clearance differ from eGFR?
Creatinine clearance (CrCl) estimates renal function without adjusting for body surface area, while eGFR is normalized to 1.73 m². CrCl also includes tubular secretion of creatinine, so it slightly overestimates true GFR.
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⚠ Medical Disclaimer
This tool is for educational and informational purposes only. It is not intended to replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional for clinical decisions.